An incident case-referent study on plasma enterolactone and breast cancer risk.

January 1, 2002 Human Health and Nutrition Data 0 Comments

An incident case-referent study on plasma enterolactone and breast cancer risk.

Year: 2002
Authors: Hult?n, K., Winkvist, A., Lenner, P., Johansson, R., Adlercreutz, H., Hallmans, A.
Publication Name: Eur. J. Nutr.
Publication Details: Volume 41, Pages 168-176.


Objective: Using a nested case-referent design, we evaluated the relationship between plasma levels of the lignan enterolactone and the risk of developing breast cancer.                                              Methods: 248 cases and 492 referents were selected from three population-based cohorts in northern Sweden. Blood samples were donated at enrolment. All blood samples were stored at –80 °C. Cases and referents were matched for age, date of blood sample and sampling centre. Breast cancer cases were identified through the regional and national cancer registries.                                               Results: Plasma enterolactone was lower among smokers in all cohorts and in subjects
with BMI<23 and BMI>28 in one of the cohorts. Low plasma concentrations of enterolactone, below the 12.5th percentile (mean plasma enterolactone 2.9 nmol/l), were associated with an increased risk of breast cancer. Also, high values of plasma enterolactone, above the 87.5th percentile (mean plasma
enterolactone 58.2 nmol/l) were significantly associated with an increased breast cancer risk among
women from two cohorts with only incident cases and a higher number of pre-menopausal women.
High plasma enterolactone concentrations among older women from a mammary screening project with
mostly prevalent cases were associated with a non-significant slightly reduced breast cancer risk. Conclusion: Very low plasma concentrations of enterolactone were associated with an increased breast
cancer risk in all three cohorts. In two of the cohorts,with only incident cases, very high plasma concentrations were also associated with an increased breast cancer risk. In the third cohort with
mainly screen-detected cases from a mammary screening program, high plasma enterolactone concentrations were associated with a weak decreased breast cancer risk. Author's Abstract.

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