Dietary Linolenic Acid-Method Increase in Vascular Prostacyclin Formation.

January 1, 1996 Human Health and Nutrition Data 0 Comments

Dietary Linolenic Acid-Method Increase in Vascular Prostacyclin Formation.

Year: 1996
Authors: H Rupp, M Turcani, T Ohkubo, B Maisch, C G Brilla.
Publication Name: Mol. Cell Biochem.
Publication Details: Volume 168; Numbers 1-2; Page 117.


The hypolipidemic effects of ALA have been well established, however, the hypotensive effects have not been studied extensively. The objective of the present study was to define the vascular effects of an enhanced dietary ALA intake. Twenty-eight spontaneously hypertensive rats were fed diets containing various levels of LA and ALA. Groups of seven rats each were fed a 3% sunflower oil (44% LA) diet or the same diet supplemented with 1, 2.5 or 5% flaxseed oil containing 62% ALA. The results showed a close correlation between dietary content of ALA and the incorporation into PL of aorta of SHR in that ALA was incorporated up to 12% in the aorta of rats fed 5% flaxseed oil. The EPA content, however, did increase but was the elevation was not significant. The content of AA and docosatetraenoic acid was reduced in rats fed the 5% flaxseed oil diet. The generation of 6-keto-PGF1-, the degradation product of PGE1, was significantly increased in rats fed the 2.5% and 5% flaxseed oil diets. TXB2, PGE2 and PGF2?? levels were not significantly altered. The high systolic and diastolic blood pressure typical of SHR was significantly reduced following the ALA diets. The ALA diet was associated with an increase in PGE1 formation and lower vascular AA content. Since PGE1 is the most potent endogenous inhibitor of platelet aggregation, the authors concluded that these results would be expected to be beneficial in the prevention of hypertension and other similar vascular disorders.

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