Effect of estrogenic compounds (estrogen or phytoestrogens) combined with exercise on bone and muscle mass in older individuals

January 1, 2008 Human Health and Nutrition Data 0 Comments

Effect of estrogenic compounds (estrogen or phytoestrogens) combined with exercise on bone and muscle mass in older individuals

Year: 2008
Authors: Chilibeck, P.D., Cornish, S.M.
Publication Name: Appl Physiol Nutr Metab
Publication Details: Volume 33; Pages 200-212

Abstract:

Exercise has a beneficial effect on bone, possibly by stimulating extrogen receptor a. Because estrogen up-regulates this receptor, estrogen therapy combined with exercise training may be optimal for increasing bone mineral density. Studies combining estrogen therary and exercise training in postmenopausal women show mixed results, but indicate that the combination of interventions may be more effective for increasing bone mass than either intervention alone. Plant-like estrogens (i.e. phytoestrogens such as soy isoflavones) may act as weak estrogen agonists or antagonists, have small benficial effects on bone, and may interact with exercise for increasing bone mineral density. Phytoestrogen derived from flaxseed (flax lignans) has not been evaluated as extensively as soy isoflavones and thus its effect on bone is difficult to determine. Estrogen or soy isoflavones given to postmenopausal women results in a small increase in lean tissue mass that may be mediated through estrogen receptor a on muscle or through decreased inflammation. Author's Abstract.



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