Impact of Denutrition and lipid quality for renutrition on plasma fatty acids and inflammatory markers in old rats

January 1, 2014 Human Health and Nutrition Data 0 Comments

Impact of Denutrition and lipid quality for renutrition on plasma fatty acids and inflammatory markers in old rats

Year: 2014
Authors: Bernadette, A.
Publication Name: ISSFAL International Congress, Stockholm, Sweden June 28 – July 1
Publication Details: ID# Tuesday S12.05


Denutrition is common among older people and is associated to many pathologies. Objectives: To evaluate the impact of denutrition and lipid quality of renutrition diets on plasma fatty acids (FA) of old rats. Procedure The following groups of rats (24 month old) were studied:  Control: fed ad libitum with a 4 percent lipid control diet (soya oil, 8 percent LA, 53 percent LA) denutrition fed for 3 months with half quantity of control diet (12 vs 24g per d)  Two groups were re fed for 1 month after denutrition with 6 percent lipid diet  R1: soya oil  R2: blend of dairy fat and rapeseed and DHA (4.9 percent ALA, 10 percent LA) Results Control, malnourished, R1 and R2 rats received respectively 0.08, 0.04, 0.12 and 0.07 g per day of ALA. Impact of denutrition: Denutrition decreased plasma ALA (45 percent; p less 0.01) and n3 long chain (LC) FA (20 percent; p less 0.05) but slightly increased n6 FA (LA and arachidonic acid (AA)), resulting in a 2.5 fold increase in the proinflammatory AA to EPA ratio vs. controls. Impact of renutrition: R1 diet (soya) restored n3FA, n6FA and the proinflammatory AA to EPA ratio to similar levels to controls, except for DHA which decreased to even lower levels than those observed after the denutrition period (22 percent p less 0.05). R2 diet (dairy fat  Rapeseed DHA) increased n3 FA to levels higher than controls and renutrition R1 levels (EPA plus 300 percent p less 0.001 and DHA plus 2040 percent p less 0.002) and reduced n6 FA levels (LA:24 percent  and AA 33 percent p less 0.001), resulting in a 5 fold decrease in proinflammatory
AA to EPA and AA to n3 LC ratios vs. controls. Conclusions Denutrition in old rats induced a specific loss of plasma n3FA and led to a proinflammatory status, which can both be restored by a renutrition diet with soya (R1), except for DHA. In contrast, a renutrition diet with dairyfat rapeseed DHA, strongly increased LCn3 (EPA, DHA) and simultaneously decreased n6FA inducing a drastic reduction of the proinflammatory ratios to much lower levels than those of control or denutrition groups and could therefore offer large benefits during aging. (Authors abstract)

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