Inflammation and metabolic disorders.

January 1, 2006 Human Health and Nutrition Data 0 Comments

Inflammation and metabolic disorders.

Year: 2006
Authors: Hotamisligil, G.S.
Publication Name: Nature.
Publication Details: Volume 444; Number 7121; Pages 860-7.


Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pathogen-sensing systems have been evolutionarily conserved throughout species. As a result, immune response and metabolic regulation are highly integrated and the proper function of each is dependent on the other. This interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease. Collectively, these diseases constitute the greatest current threat to global human health and welfare. Author's Abstract.

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