Protective Effect of Flaxseed Oil on Renal Injury in Hyperlipidaemic Rats: The Effect of Flaxseed Oil on Hyperlipidaemia

January 1, 2010 Human Health and Nutrition Data 0 Comments

Protective Effect of Flaxseed Oil on Renal Injury in Hyperlipidaemic Rats: The Effect of Flaxseed Oil on Hyperlipidaemia

Year: 2010
Authors: Akpolat, M. Kanter, M. Topcu-Tarladacalisir, Y. Aydogdu, N.
Publication Name: Phytotherapy Research
Publication Details: doi:10.1002/ptr.3334


This study evaluated the possible effects of flaxseed oil on renal damage associated with hyperlipidaemic rats. Wistar albino male rats were divided into three groups. Group I was fed with a pellet chow. Group II was fed with a high cholesterol diet (HCD) consisting of 5% cholesterol and 0.35% cholic acid added to the pellet chow. Group III was fed with the same HCD, but were orally treated with a dose of 15 mg/kg body wt/day flaxseed oil. Flaxseed oil treatment started 1 week before and continued throughout the 22 weeks of the HCD. At the end of the experiment, renal tissue and blood samples were collected. The biochemical and histopathological findings confirmed renal damage in hypercholesterolaemia conditions. Flaxseed oil reduced the hypercholesterolaemia induced increase in the serum levels of total cholesterol, LDL and urea. Oil red O stain revealed that lowered serum lipid was accompanied by a decreased deposition of neutral lipid. Flaxseed oil effectively reversed these abnormalities, verifying the protective effects of flaxseed oil in ameliorating renal injuries associated with hypercholesterolaemia. (Author's Abstract)
The relationship between hypercholesterolaemia and kidney damage is well known.  Hyperlipidaemia can be induced by the administration of a high cholesterol and lipid diet in laboratory animals. No studies to date had assessed the effects of flaxseed oil on hyperlipidaemic renal injury. The aim of this study was to investigate whether flaxseed oil has a protective morphological or biochemical effect on hyperlipidaemic kidneys. Abnormalities in lipid metabolism appear to play a pathogenic role in progressive renal diseases and hypercholesterolaemia is considered an independent risk factor for renal injuries. In this study, the levels of total cholesterol and LDL were increased in the serum of HCD-fed rats.  Treatment with flaxseed oil decreased the serum lipid levels, normalizing elevated serum concentrations of total cholesterol and LDL and depressed HDL levels and may be due to decreasing cholesterol absorption. The mechanism by which hyperlipidaemia exerts its deleterious effect on the kidneys is still largely unknown. Hyperlipidaemia may mediate renal injury by directly acting on the resident cells of the kidneys.  In this study, it was shown morphologically that most of interstitial and tubular cells in hypercholesterolaemic rat kidneys contained numerous neutral lipid droplets.  In the flaxseed oil-treated rat kidneys, a marked reduction in oil red O-positive neutral lipid deposits was shown, suggesting that its effect is hypolipidaemic. The authors conclude that flaxseed oil causes a significant decrease in the serum cholesterol and lipid levels in hyperlipidaemic rats, both biochemically and morphologically.  The hypolipidaemic potential of flaxseed oil in the kidneys suggest the efficacy of flaxseed oil in preventing hyperlipidaemia-induced renal injury. (Editor's comments)

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